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tooluniverse-pharmacovigilance
Systematic drug safety analysis using FAERS adverse event data, FDA labeling, PharmGKB pharmacogenomics, and clinical trial safety signals. KEY PRINCI...
tooluniverse-phylogenetics
Comprehensive phylogenetics and sequence analysis using PhyKIT, Biopython, and DendroPy. Designed for bioinformatics questions about multiple sequence...
tooluniverse-polygenic-risk-score
Build and interpret polygenic risk scores for complex diseases using genome-wide association study (GWAS) data. Use Cases: "Calculate my genetic risk ...
tooluniverse-precision-medicine-stratification
Transform patient genomic and clinical profiles into actionable risk stratification, treatment recommendations, and personalized therapeutic strategie...
tooluniverse-precision-oncology
Provide actionable treatment recommendations for cancer patients based on their molecular profile using CIViC, ClinVar, OpenTargets, ClinicalTrials.go...
tooluniverse-protein-interactions
Comprehensive protein interaction network analysis using ToolUniverse tools. Analyzes protein networks through a 4-phase workflow: identifier mapping,...
tooluniverse-protein-structure-retrieval
Retrieve protein structures with proper disambiguation, quality assessment, and comprehensive metadata. IMPORTANT: Always use English terms in tool ca...
tooluniverse-protein-therapeutic-design
AI-guided de novo protein design using RFdiffusion backbone generation, ProteinMPNN sequence optimization, and structure validation for therapeutic pr...
tooluniverse-sequence-retrieval
Retrieve DNA, RNA, and protein sequences with proper disambiguation and cross-database handling. IMPORTANT: Always use English terms in tool calls (ge...
tooluniverse-single-cell
Comprehensive single-cell RNA-seq analysis and expression matrix processing using scanpy, anndata, scipy, and ToolUniverse. Designed for both full scR...
tooluniverse-spatial-transcriptomics
Comprehensive analysis of spatially-resolved transcriptomics data to understand gene expression patterns in tissue architecture context. Combines expr...
tooluniverse-structural-variant-analysis
Systematic analysis of structural variants (deletions, duplications, inversions, translocations, complex rearrangements) for clinical genomics interpr...